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 Part Three - Heredity and the Genome 179

 10. Genetics: Mendel and Beyond 206

10.1 What Are the Mendelian Laws of Inheritance? 207
Mendel brought new methods to experiments on inheritance 208
Mendel devised a careful research plan 208
Mendel’s first experiments involved monohybrid crosses 209
Alleles are different forms of a gene 211
Mendel’s first law says that the two copies of a gene segregate 211
Mendel verified his hypothesis by performing a test cross 213
Mendel’s second law says that copies of different genes assort independently 213
Punnett squares or probability calculations: A choice of methods 214
Mendel’s laws can be observed in human pedigrees 216

10.2 How Do Alleles Interact? 217
New alleles arise by mutation 217
Many genes have multiple alleles 218
Dominance is not always complete 218
In codominance, both alleles at a locus are expressed 219
Some alleles have multiple phenotypic effects 219

10.3 How Do Genes Interact? 219
Hybrid vigor results from new gene combinations and interactions 220
The environment affects gene action 220
Most complex phenotypes are determined by multiple genes and the environment 221
Genes on the same chromosome are linked 223
Genes can be exchanged between chromatids 223
Geneticists can make maps of chromosomes 224
Linkage is revealed by studies of the sex chromosomes 225
Genes on sex chromosomes are inherited in special ways 226
Humans display many sex-linked characters 227

10.5 What Are the Effects of Genes Outside the Nucleus? 228

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