CHIME proteins

• Diphtheria toxin, dimer 1DDT.pdb
• Diphtheria toxin, monomer 1MDT.pdb
• Structural requirements of antibody to Haemophilus influezae type b, 1HOU.pdb
• Tetanus toxin, fragment ,1AF9.pdb
• Poliovirus (type 1) native empty capsid, 1POV.pdb
• Poliovirus (type 2) coat protein, 1EAH.pdb
• Yop-51 from Yersinia pestis plasmid 1YPT.pdb

Web Links

• PDB search site
• Center for Disease Control (CDC) Web Search (See Vaccine Recommendations for Diphtheria, Hib, Polio, Plague, etc.)
• CDC Morbidity and Mortality Weekly Report, MMWR Search
• National Institutes of Health, PubMed Search
• Virtual Hospital (See Children's Hospital of Iowa)
• CDC-MMWR on Plague Vaccine
• The Black Plague, Links
• Boise State Univ., Black Death in the History of Western Civilitation
• Univ. of Chicago, Dr. Jose Quintans Lecture on the Plague

Further Reading

1. Immune Response to Infectious Diseases (Chapter 17) and Vaccines (Chapter 18) in R. A. Goldsby, T. J. Kindt, and B. A. Osborne. Kuby Immunology, 4th edition, W. H. Freeman and Co., pp. 425-465, 2000.
2. B. Purves, G. Orians, C. Heller and D. Sadava. Life - The Science of Biology,  5th edition, Sinauer and W. H. Freeman and Co., pp. 400-427, 503 and 540-546, 1998.
3. L. Stryer. Biochemistry,4th edition, W. H. Freeman and Co. pp. 36, 140, 906 and 941, 1995.
4. P. D. Hoeprich and M. C. Jordan. Infectious Diseases, 4th edition, J. B. Lippincott Company, pp. 318-326, 1114-1132, 1142-1149 and 1296-1306, 1989.
5. Stanley A. Plotkin and Edward A. Mortimer, Vaccines, 2nd edition, W. B. Sunders Company, pp. 4, 5, 41-56, 337-386, 137-227 and 961, 1994.
6. Immunotherapy and Vaccines, Stanley J. Cryz ed., VCH Publishers, pp. 13-14, 39-40 and 52-53, 1991.
7. R. D. Perry and J. D. Fetherston.  Yersinia pestis - Etiologic Agent of Plague. Clinical Microbiology Reviews 10:35-66, 1997.
8. J. B. Robbins, R. Schneerson, P. Anderson, D. H. Smith, "Prevention of systemic infections, especially meningitis, caused by Haemophilus influenzae type b. Impact on public health and implications for other polysaccharide-based vaccines," Journal of the American Medical Association, 276:1181-1185, 1996.
9. B. Rombaut and J. P. M. Jore, "Immunogenic, non-infectious polio subviral particles synthesized in Saccharomyces cerrevisiae," Journal of General Virology, 78:1829-32, 1997.

Acknowledgements

• Dr. Chun-Hsien Huang, Senior Chemist, North American Vaccine, Inc., Columbia, MD
• Dr. Gregory Plano, Assistant Professor, Dept. of Microbiology, Univ. Miami School of Medicine, Miami, FL.
• Virginia Scofield, University of Southern California, Los Angeles, CA.