CHIME proteins

• Immunoglobulin A (IgA), 1IGA.pdb
• Transforming Growth Factor- (TGF-), 1TGF.pdb and 2TGI.pdb
• TGF- receptor Type I, fragments, 1B6C.pdb and 1TBI.pdb
• Smad4, active fragment, 1DD1.pdb
• Smad3, fragment 1MHD.pdb
• DNA binding partner (DNA binding PROTEIN, 3ULL.pdb)  (Note: must verify same protein)

Web Links

• PDB search site
• The International Cytokine Society
• The Weizmann Institute of Science - Genome and Bioinformatics (Immunology links)
• The Cytokines Web:
• COPE, Cytokines Online Pathfinder Encyplopedia (See B-cell differentiation factors, Cytokine definition, etc.)
• Universiity of Virginia, Integrins
• The Integrin Page

Further Reading

1. Cytokines (Chapter 12) in R. A. Goldsby, T. J. Kindt, and B. A. Osborne. Kuby Immunology, 4th edition, W. H. Freeman and Co.,  pp. 303-327, 276-281, and 294-295, 2000.
2. H. Lodish, A. Berk, S. L. Zipursky. P. Matzudaira, D. Baltimore and J. Darnell. Molecular Cell Biology, 4th edition, W. H. Freeman and Co., pp. 394-6, 524, 848-909,1006-1007, 1999.
3. B. Purves, G. Orians, C. Heller and D. Sadava. Life - The Science of Biology,  5th edition, Sinauer and W. H. Freeman and Co., pp. 114-115 and 850-858, 1998.
4. L. Stryer. Biochemistry,4th edition, W. H. Freeman and Co. pp. 325-360, 1995.

   R.L. Coffman, D.A. Lebman and P. Rothman.  Mechanism and regulation of immunoglobulin isotype switching.  Advances in Immunology 54:229-270, 1993

5. Y. Zhang and R. Derynck.  Regulation of Smad signalling by protein associations and signalling crosstalk.  Trends in Cell Biology 9:274-279, 1999.
6. R. W. Padgett.  Intracellular signalling: fleshing out the TGF-beta pathway.  Current Biology 9:R408-411, 1999.

Acknowledgements

Derived from H. Lodish, et al., Molecular Cell Biology text and CD-ROM, 4th edition, © 2000 W. H. Freeman and Co. and Sumanas, Inc.

Virginia Scofield, University of Southern California, Los Angeles, CA.