• An Increased Focus on Computer-Based Statistical Methods. Computational formulas have also been replaced throughout with simpler structural formulas for ease of understanding.
• Matrix methods. Matrix methods are introduced in new sections on multiple regression, general linear models, ancova, and curvilinear regression. A new appendix on matrix algebra is also included.
• New Chapter on Statistical Power and Sample Size Estimation. The new edition features a new chapter that covers statistical power, measures of effect size, and the estimation of sample size required for tests and for confidence limits.
• Up-to-Date Coverage of Key Developments in Biostatistics. This edition includes the most up-to-date coverage of key topics such as meta-analysis and trends in the discipline such as the use of resampling methods.